Process for preparation of phthalic-acid salts of cotarnin and product resulting therefrom.



UNITED STATES P TENT OFFICE.

MARTIN FREUND, OF FRANKFORT-ON-THE-MAIN, GERMANY.

PROCESS FOR PREPARATION OF PHTHALIG-ACID SALTS OF COTARNIN AND PRODUCT RESULTING THEREFROM.

Specification of Lettem-Patent.

Patented July 7, 1905.

To all whom 'it may concern:

Be it known that I, MARTIN FREUND, a subject of the Emperor of Germany, and a resident of Frankfort-on-the-Main, Germany, have invented a new and useful Process for the Preparation of Phthalic-Acid Salts of Cotarnin and a Product Resulting Therefromyof which the following is a specification.

This invention consists broadly in the treatment of cotarnin with hthalic acid anhydrid under suitable con itions and the acid cotarninphthalate produced by employing equal molecular proportions.

Anhydrids of monobasic organic acids are decomposed with the formation of acid amids by means of ammonia, and also by rimary and secondary amins. In a whol y ana ogous manner anhydrids of dibasic acids act, being converted into amido acids. Thus phthalic acid anhydrid withammonia yields:

H4\ 00211 with ethyl anllm C H' O,.NH.CH with phthalic acid anhydrid would yield the compound or the cotarnin salt of this acid. Unexpectedly. there is obtained from one molecular pro ortion of phthalic acid anhydrid and two 'mo ecular pro ortion of cotarnin not the cotarnin salt of t e substituted phthalamic acid but neutral cotarnin phthalate and from one molecular proportion of the anhydridand one molecular proportion of the cotarnin the acid phthalate 00 1i Since I understand that I am the first one to produce phthalic acid salts by treatment of cotarnin with hthalic-acid anhydrid, I do not wish to be un ers'tood aslimiting myself in any way to the details of such treatment and would consider any details which fall within the scope of the appended claims to be the equivalents of these which I will now set forth as an example of the method of carrying out my invention.

Preparation of the neutral phthalate.-474 parts of cotarnin and 148 arts of finely powdered phthalic acid anhy rid are covered with absolute ether and stirred or shaken up until a portion taken out is com letely and easily soluble in water. The ro uct is then ,filtcred oil and freed from ad ering etherin while being constantly stirred or shaken up, .237 parts of cotarnin are introduced in pertions into the mass as the reaction proceeds. As soon as a portion taken'ou't 1s clearl Soluble in warm water, the product is fil tered.

The new product, cotarnin acid phthalate, may be recognized by the followin characterlstics: It is less soluble in cold water than the neutral phthalate of cotarnin and when heated it decomposed at about 130 centigrade. It is a micro crystalline owder of brimstone color having the fo owing and decomposition at about 130 centigradetv Having thus described my inventlon, I claim as new and desire to secure by Letters Patent:

1. The rocess for the preparation of phthalic acid salt of cotarnin b reaction of the same with hthalic acid an ydrid in an indifferent me ium.

2. As a new article of manufacture acid cotarnin phthalate consisting in a microcrystalline powder of brimstone color decomposing at about 130 C. and'having the following formula:

In testimony whereof, I have hereunto I signed my name in the scribing witnesses.

presence of two sub- Witnesses JEAN GRUND, CARL Gmmn. 

